Know Your Chances
This book has been shown in two randomized trials to improve peoples' understanding of risk in the context of health care choices.
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McMaster Evidence-Based Clinical Practice Workshop Resources – Systematic review module
The Systematic review module resources provided to the attendees at the McMaster Evidence-Based Clinical Practice Workshop.
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Understanding Health Research: A tool for making sense of health studies
An interactive online tool designed to help anybody to understand scientific health research evidence.
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The Slippery Slope: Is a Surrogate Endpoint Evidence of Efficacy?
A discussion of the dangers of relying on surrogate outcome measures.
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University of Western Australia: Bias Minimisation, randomisation and blinding
University of Western Australia’s explanation of why random allocation to comparison groups and blinding (if possible) are important.
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Is the therapy clinically useful?
An article from the PEDro database on whether a treatment is useful.
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Evidence-Based medicine in Pharmacy Practice
An article by Suzanne Albrecht on Evidence-Based Medicine in Pharmacy Practice.
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Goals and tools in Meta-analysis
Meta-analysis in Michigan State University’s Evidence-Based Medicine Course.
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Evaluating relevance
How to evaluate relevance of research in Michigan State University’s Evidence-Based Medicine Course.
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Limitations of current clinical practice
Discussion of the need to recognise the limitations of current clinical practice in Michigan State Univ’s Evidence-Based Medicine Course.
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Evidence-based medicine
The European Patients’ Academy web-based introductory course on Evidence-Based Medicine.
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Apply the results to your patients
A Duke Univ. tutorial explaining how to address the question: how relevant is the research evidence to the needs of my patient?
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Delfini: Critical appraisal matters
A 20-minute slide cast discussing how reliable evidence and critical appraisal can help to improve health outcomes.
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Julia Belluz – Lessons from the trenches of evidence-based health journalism at Vox.com
20-minute talk by Julia Belluz on the need to bring the cultures of health journalism and EBM together.
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The surrogate battle – is lower always better?
James McCormick recruits a furious Fuhrer to point out that taking drugs to lower surrogate measures of ill health is a confidence trick.
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Building evidence into education
Ben Goldacre explains why appropriate infrastructure is need to do clinical trials of sufficient rigour and size to yield reliable results.
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Anecdotes are great – if they convey data accurately
Ben Goldacre gives examples of how conclusions based on anecdotes and biased research can be damagingly misleading.
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Unsubstantiated and overstated claims of efficacy
A 32-slide presentation on misleading advertisements and FDA warnings prepared by PharmedOut.
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Introduction to Evidence-Based Medicine
Bill Caley’s 26 slides with notes used as an ‘Introduction to Evidence-Based Medicine’.
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Applying evidence to patients
A 27-minute talk on ‘Applying Evidence to Patients’, illustrated by 17 slides, with notes.
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Defining clinical questions
An 8-min talk on ‘Defining Clinical Questions’ illustrated by 10 slides, with notes.
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Applying the evidence
Six key slides produced by the University of Western Australia on applying evidence in practice.
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Appraising the evidence
Six key slides produced by the University of Western Australia to introduce critical appraisal.
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Making the most of the evidence in education
A pamphlet to guide people using research evidence when deliberating about educational policies.
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Tips for understanding Non-inferiority Trials
A non-inferiority experiment endeavours to show that a new intervention is ‘not unacceptably worse’ than the comparison intervention.
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GenerationR – The importance of involving children and young people in research
3/3, 22-min video at the launch of GenerationR, a network of young people who advise researchers.
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Generation R – The need to reduce waste in clinical research involving children
1/3, 14-min video at the launch of GenerationR, a network of young people who advise researchers.
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Surrogate Endpoints in EBM: What are the benefits and dangers?
What are surrogate outcomes, their pros and cons, and why you should be cautious in extrapolating from them to clinical decisions.
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Surrogate endpoints: pitfalls of easier questions
A blog explaining what surrogate endpoints are and why they should be interpreted cautiously.
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Making sense of randomized trials
A description of how clinical trials are constructed and analysed to ensure they provide fair comparisons of treatments.
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Making sense of results – CASP
This module introduces the key concepts required to make sense of statistical information presented in research papers.
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Toma de Decisiones Compartidas
¿Por qué nosotros, los pacientes, debemos participar en la toma de decisiones médicas importantes?
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Using the results of up-to-date systematic reviews of research
Trustworthy evidence from research is necessary, but not sufficient, to improve the quality of health care.
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Surrogate markers may not tell the whole story
A webpage explaining the limitations of using surrogate outcome markers in clinical research.
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Composite Outcomes
Fair comparisons of treatments should measure important outcomes and avoid dependence on surrogate outcome measures.
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Biomarkers unlimited
Fair comparisons of treatments should measure important outcomes and avoid dependence on surrogate outcome measures.
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Does it work?
People with vested interests may use misleading statistics to support claims about the efects of new treatments.
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Introduction to clinical trials: lay-friendly video
This lay-friendly video introduction to clinical trials was created by the European Communication on Research Awareness Needs Project.
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Methodology of clinical trials
Eurordis training on the methodology of clinical trials for representatives of patients’ organisations.
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How to read articles about healthcare
This article 'How to read health news behind the headlines', by Dr Alicia White, explains how to assess health claims in the media.
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Can measurements show if a treatment works?
An article discussing errors to avoid when testing treatments.
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Be careful with composites
Kevin Lomangino's article discusses the limitations of composite outcomes and surrogate markers.
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Disease outcomes vs. patient-relevant outcomes
An e-Learning module consisting of 3 slides and 2-min commentary on why it is important to treat patients, not numbers from tests.
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Viva la Evidence!
A brilliant song and video by James McCormack explaining the basics of evidence-based medicine.
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Some Studies That I Like to Quote
This short music video encourages health professionals to use evidence to help reach treatment decisions in partnership with patients.
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On taking a good look at ourselves
Iain Chalmers talks about failings in scientific research that lead to avoidable harm to patients and waste of resources.
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Involving citizens to improve healthcare
‘The confluence of interest between advocacy groups, those who sell treatments, and those who prescribe them makes for a potent […]
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Lay people help to rethink AIDS
‘Credibility struggles in the AIDS arena have been multilateral: they have involved an unusually wide range of players. And the […]
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A key partnership
‘People-focused research in the NHS simply cannot be delivered without the involvement of patients and the public. No matter how […]
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Patients’ choice: David and Goliath
‘Who has the power to see that research questions actually address the greatest needs of patients in all their misery […]
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Psoriasis patients poorly served by research
‘Few trials involved comparison of different options or looked at long-term management. The duration of studies is unconvincingly brief in […]
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Who decides what gets studied?
Clearly this situation is unsatisfactory, so how has it come about? One reason is that what gets studied by researchers […]
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Questions that are important for patients
Researchers in Bristol decided to pose a fundamental question: ‘To what extent are questions of importance to patients with osteoarthritis […]
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Epidural analgesia for women in labour
The importance of assessing outcomes that matter to patients is clearly illustrated – in a very negative fashion – by […]
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A commonsense approach to informed consent in good medical practice
‘What is missing in the debate surrounding informed consent is the true nature of patient understanding, what information patients want […]
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What does a “significant difference” between treatments mean?
Well, this is a trick question, because ‘significant difference’ can have several meanings. First, it can mean a difference that […]
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When practitioners disagree
In this sub-section Introduction (this page) Caffeine for breathing problems in premature babies Antibiotics in pre-term labour Breast cancer Introduction […]
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Herceptin
Commercial companies are not alone in trumpeting the advantages of new treatments while down-playing drawbacks. Professional hype and enthusiastic media […]
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